Progesterone oral delivery

Potluri P, Betageri GV (2006) Mixed-micellar proliposomal systems for enhanced oral delivery of progesterone. Drug Deliv 13 227-232. 

Because of the beneficial effects of the vaginal delivery of estrogens and progesterone in comparison to their oral delivery, various vaginal preparations (tablets, suppositories, gels, rings) of these agents are now available, for use ... 

Control of solubility Itraconazole/p-CD oral delivery form (improved solubility) glibomuride/p-CD testosterone (progesterone)/branched CD lotepredrol/a-CD (nasal delivery form) flufenamic acid/triacetyl-P-CD complex (limited solubility) hydrocortisone, digitoxin, diazepam, indomethacin, chlorpromazine. 

Use of Drugs by the Lactating Mother. If oral contraceptives are taken sooner than 6 weeks after childbirth, the amount of breast milk a woman produces may be diminished, (Hormones such as estrogen and progesterone in these pills reduce milk production.) Clinical experience shows that the majority of women will not have difficulty producing an adequate amount of milk if they do not use oral contraceptives for 6 weeks after delivery. Hence, they should substitute another form of birth control. 

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