Progestagens adverse effects

For a complete account of the adverse effects of progestagens, readers should consult the following monographs as well as this one ... 

Hormonal contraception rehes on the actions of estrogens and progestagens, of which oral contraceptives contain a mixture. The adverse effects of the separate components are discussed in other monographs. 

Estrogens and progestagens used for postmenopausal hormone therapy still are prescribed commonly in the United States, especially for the management of menopausal vasomotor symptoms. Even before pnblication of the WHI findings, only a fraction of women filled then-hormone therapy prescriptions, and only 25% to 40% continned to take postmenopausal hormone therapy for more than 1 year." This may be due to women s attitudes toward hormone therapy or aresnlt of fear about adverse effects and associated risks. Hormone therapy nse in the United States declined substantially after dissemination of the WHI study results." "... 

The manufacturer also points out that combined oral contraceptives (and presumably the combined hormonal contraceptive patch) must not be taken with co-cyprindiol. To do this would be analogous to doubling the ethinylestradiol dose with consequent increased risk of adverse effects. In addition, some of the progestagens in combined oral contraceptives have weak androgenic effects, which could oppose the benefits of cyproterone. 

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