Profound knowledge variation

Educating management is no less important. In particular, this includes education in areas that Deming called profound knowledge variation, psychology, and the theory of systems. These areas of knowledge are critical to the effective leadership of process improvement. 

Remember that the goal of SPC is to make sense of the data and variation collected from direct observation of product quality or a process in a way that helps us to expose hidden properties. Only then can we make necessary corrections and predict the outcome of those corrections. This whole process then brings us to an appreciation of a system, provides profound knowledge about the system, and fulfills our urge to learn and create. ... 

Profound knowledge comprises four disciplines that Deming felt were fundamentally important to business statistics, or the mathematics of variation psychology the theory of knowledge and the theory of systems. We shall treat each of these briefly in order to illustrate the relevance of each to management. 

Variations in the level of aminoacylation of tRNA arising from the altered specificity of an aminoacyl-tRNA synthetase or from an amino acid depletion would be expected to exert a profound effect on the rate and level of protein synthesis. There are reports that qualitative changes in aminoacyl-tRNA synthetases may occur during embryo development [58] and in different tissues and organs [15] and that multiple synthetases may occur [59]. However, with the knowledge that mitochondria contain unique synthetases, a reexamination of these data in terms of the localization of the enzymes would help in clarification. 

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