Product analogs, irreversible inhibition

It is possible that the schizophrenic episode which followed our experiment may have resulted from an irreversible inhibition of MAO. Some MAO inhibitors used therapeutically as antidepressants (notably iproniazid) can bind irreversibly to the enzyme, triggering a long-term inhibition that can only be mitigated through the production of new enzymes by protein synthesis. Studies of irreversible inhibition have shown that full recovery of normal MAO activity can require a period of ten to twenty days (Planz et al. 1972). While harmine and its analogs are known to exhibit strong MAO inhibition, this action is reversible and is on the order of... 

Rhizobitoxine. Various Rhizoblum. laponlcum strains produce rhizobitoxine [75], whose structure was reported In 1972 (2691. Although the host of this bacterium Is soybean, this compound Is also phytotoxic to many other plant species. This phytotoxin Is an analog of cystathionine and acts as an Irreversible Inhibitor of -cystathlonase which catalyzes production of homoserlne from cystathionine (2701. Rhizobitoxine also Inhibits ethylene production from methionine (2711. as does a similar phytotoxin, 2-am1no-4-methoxy-3-eno1c acid (28). 

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