Process Design creative aspects

One reason for focusing on the first step of the design process in this chapter on creativity is that not only is the structure of the process different in the two steps, but the knowledge and skills required are also significantly different, and the development of technology has led to the creative aspect of design being shifted... 

Placed in a completely different and far more fixedly structured domain, the results of the DWQ project were not directly transferable to the CRC 476 IMPROVE. For the support of creative design processes, different approaches were - and are - necessary. Yet the approach of applying methods of meta modeling in domain and application models was expected to succeed there as well. Especially the use of ConceptBase, as described before, was used to achieve a sound conceptual and ontological basis for the modeling aspects, the process extensions to Data Warehousing as researched in the subproject Cl, and the meta process and product repository of the subproject B1. 

The API, as an outcome of the designed processes, needs to be fit for use in the formulating of the drug product where the requirements need to be well defined and understood. Increased API complexity, lower solubility and bioavailability, less stable APIs, and more complicated intelligent formulations as a result impose specific form requirements (salts, particles, etc.) calling for the process chemist s creativity and expertise to find adequate solutions. Polymorphism continues to be an important aspect to be managed, and there is an excellent chapter on crystallization and polymorph controls in this book. 

Designing with composites, as with any other material, is a combination of art and science. The creative element of the design process is often associated with shape, geometry, colour and surface texture, that is with the visual and tactile attributes of the structure or component. Beneath the surface are the technical aspects of the design the choice of materials, their properties, loads, failure criteria, fabrication and processing methods. 

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