Probenecid Levofloxacin

Levofloxacin 500 mg PO daily for 14 days with or without metronidazole 500 mg PO twice daily for 14 days Ceftriaxone 250 mg IM single dose and probenecid 1 g single dose, plus doxycycline 100 mg PO twice daily for 14 days with or without metronidazole, 500 mg PO twice daily for 14 days Third-generation cephalosporin plus doxycycline 100 mg PO twice daily for 14 days with or without metronidazole 500 mg PO twice daily for 14 days... 

PROBENECID QUINOLONES -CIPROFLOXACIN, LEVOFLOXACIN, NALIDIXIC ACID, NORFLOXACIN t ciprofloxacin, nalidixic acid and norfloxacin levels Uncertain Watch for t incidence of side-effects. Moxifloxacin, ofloxacin and sparfloxacin do not seem to interact and could be used as alternative therapy... 

The OAT family of transporters can be inhibited by probenecid. If a substrate of this family of transporters, such as penicillin, is administered concomitantly with probenecid, the dmg can have decreased renal secretion, with a resulting increase in the plasma penicillin concentration. Cimetidine is an inhibitor of members of the OAT, organic cation transporter (OCT) and OATP families of transporters This inhibition has been shown to result in a decrease in the renal excretion of substrates such as procainamide and levofloxacin, resulting in increased plasma concentrations of these dmgs. 

Gaitonde MD, Mendes P, House ES Lehr KH. the effects of cimetidine and probenecid on the pharmacokinetics of levofloxacin (J,FLX). Intersci Conf Antimicrob Agents Chemother (1995) 35,8. 

Probenecid increases the serum ieveis and/or decreases the urinary excretion of cinoxacin, ciprofloxacin, clinafloxacin, enoxacin, fleroxacin, levofloxacin, nalidixic acid and norfloxacin. The ciinicai importance of these changes is uncertain, but is seems iikeiy they wiii oniy be important in the presence of other drugs that aiso affect renai excretion. Grepafloxacin, moxifloxacin, sparfloxacin, and probably ofloxacin, appear not to interact with probenecid. 

A study in 12 healthy subjects found that although probenecid reduced the renal clearance of a single 500-mg oral dose of levofloxacin by about one-third and increased its AUC and half-life by similar amounts, the 72-hour urinary levofloxacin excretion was unaltered. ... 

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See also in sourсe #XX -- [ ]

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