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Privileged templates

It is also common to design libraries for addition to a corporate collection. A recent example from Astra Zeneca is illustrative of the approach. A set of spirocyclic diamines were identified as privileged templates, and a bis-azetidine core (Scheme 14.1), which is under represented in the AZ collection and patent literature, was selected. [Pg.385]

It is evident that all described privileged structures are heterocyclic scaffolds with various ring sizes, heteroatom distributions, and substitution patterns. The synthesis of these scaffolds was considered to be achievable by means of solid-phase chemistry, thus yielding high-dimensional libraries. No emphasis is laid on whether the template itself contains pharmacophoric elements or is just a scaffold with... [Pg.18]

Figure 1.6 Structural scaffolds that served as templates for so-called privileged structure-based combinatorial compound libraries. R-groups are depicted at positions of combinatorial variations [45],... Figure 1.6 Structural scaffolds that served as templates for so-called privileged structure-based combinatorial compound libraries. R-groups are depicted at positions of combinatorial variations [45],...
The synthetic scheme developed for the P-strand template (27.7) has proved to be robust and efficient. Utilizing this chemistry and the IRORI minikan system, we have produced well over 70 000 P-stfand mimetics based on this privileged chemotype (27.7). All compounds are examined for identity and purity by LC-MS, with a success rate of over 85% at a purity level of greater than 80%. ... [Pg.492]


See other pages where Privileged templates is mentioned: [Pg.108]    [Pg.108]    [Pg.164]    [Pg.108]    [Pg.108]    [Pg.164]    [Pg.322]    [Pg.10]    [Pg.22]    [Pg.590]    [Pg.180]    [Pg.162]    [Pg.31]    [Pg.244]    [Pg.425]    [Pg.18]    [Pg.22]    [Pg.12]    [Pg.644]    [Pg.802]    [Pg.28]    [Pg.178]    [Pg.11]    [Pg.107]    [Pg.952]    [Pg.325]    [Pg.178]    [Pg.297]    [Pg.344]    [Pg.282]    [Pg.235]    [Pg.287]   
See also in sourсe #XX -- [ Pg.108 ]

See also in sourсe #XX -- [ Pg.108 ]




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