Primary alcohols organometallic compound reaction

Reaction of organometallic compounds with carbonyl compounds a. primary alcohols from methanal (formaldehyde)... 

Perhaps the greatest use of organometallic compounds is in the transfer of alkyl groups to carbon atoms that are bound in organic molecules. For example, the reaction of a Grignard reagent with a primary alcohol can be shown as... 

This reaction is initiated by varicais compounds such as amine, water, alcohol, metal alkoxide, organometallic compound etc. The reaction initiated by primary amine is one of the best studied, and proceeds by the repetition of the attack of primary amino group towards the 5-carbonyl group of NCA. 

The reaction of organometallic compounds with formaldehyde results in primary alcohols. In the electrostatic potential maps of the example below, the electron-rich (orange-red) carbon of the butylmagnesium bromide is seen to attack the electron-poor (blue) carbon of formaldehyde to give 1-pentanol. 

Finally, a homogeneous heterobimetallic Pd(COD)Cl-SnCl3 catalyst for the 5 reactions that form a new C-C bond between primary and secondary allylic alcohols and nucleophiles such as arenes, heteroarenes, active methylene-, and organometallic compounds has been reported. Yields range from 60 to 92%. The Sf 2/Sj 2 ratio is usually high, even up to 100/0, although exceptions occur. The reaction is successful when ben-zylic and propargylic alcohols or symmetric and unsymmetric allyl ethers are used in place of allylic alcohols. 

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