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Priapism with phosphodiesterase inhibitors

Intracavernosal alprostadil has been used successfully in combination with VEDs or vasoactive agents (e.g., papaverine, phentolamine, atropine) that act by different mechanisms. Phosphodiesterase inhibitors should not be added to intracavernosal alprostadil because the combination can cause prolonged erections and priapism. [Pg.955]

A combination of phentolamine with the nonspecific smooth muscle relaxant papaverine, when injected directly into the penis, may cause erections in men with sexual dysfunction. Long-term administration may result in fibrotic reactions. Systemic absorption may lead to orthostatic hypotension priapism may require direct treatment with an -adrenoceptor agonist such as phenylephrine. Alternative therapies for erectile dysfunction include prostaglandins (see Chapter 18), sildenafil and other cGMP phosphodiesterase inhibitors (see Chapter 12), and apomorphine. [Pg.204]

Priapism is a rare adverse effect of phosphodiesterase inhibitors, particularly sildenafil and vardenafil, which have shorter plasma half-lives than tadalafil. When priapism has occurred, this has been associated with excessive doses of the phosphodiesterase inhibitor or concomitant therapy involving other erectogenic drugs. [Pg.1525]


See other pages where Priapism with phosphodiesterase inhibitors is mentioned: [Pg.209]   
See also in sourсe #XX -- [ Pg.785 ]

See also in sourсe #XX -- [ Pg.1525 ]




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