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Presystemic metabolism prevention

Wu O, George TG, Hurh E et al. Presystemic metabolism prevents in vivo antikinetoplasdd activity of Nl, N4-substituted 3,5-dinitio sulfanilamide, GB-II-150. Life Sci 2006 79 1081-1093. [Pg.47]

BUCCAL ADMINISTRATION AS A METHOD OF PREVENTING PRESYSTEMIC METABOLISM... [Pg.1075]

Studies are being performed to determine the effect of presystemic and hepatic first-pass metabolism on the toxicity and carcinogenicity of xenobiotics. For a nontherapeutic toxic substance, the existence of a first-pass effect is desirable, because the liver can bioinactivate it, preventing its distribution to other parts of the body. On the other hand, first-pass metabolism may increase its toxicity by biotransforming the toxicant to a more toxic metabolite, which can reenter the blood and exert its toxic effect. [Pg.475]

See other pages where Presystemic metabolism prevention is mentioned: [Pg.1071]    [Pg.1076]    [Pg.281]    [Pg.496]    [Pg.497]    [Pg.204]   
See also in sourсe #XX -- [ Pg.1071 ]



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Presystemic metabolism

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