Presentation and Layout of the Book

A few decades ago, pharmacokinetics, drug metabolism, and toxicology of selected clinical candidates were studied mainly during preclinical and clinical develop- 

1 van de Waterbeemd, H. and Testa, B. (2007) The why and how of absorption, distribution, metabolism, excretion, and toxicity research, in ADME-Tox Approaches, Vol. 5 (eds B. Testa and H. van de Waterbeemd), in Comprehensive Medicinal Chemistry II (series eds J.B. Taylor and D.J. Triggle), Elsevier, Oxford, UK, pp. 1-9. 

2 Hurst, S., Loi, C.-M., Broadfueher, J. and El-Kattan, A. (2007) Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bioavailability of rats and humans. Expert Opinion on Drug Metabolism and Toxicology, 3, 469—489. 

Medicinal Chemistry II (series eds J.B. Taylor and D.J. Triggle), Elsevier, Oxford, UK, pp. 11-30. 

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