Preparations and Dosages

Preparation and dosage vary considerably with the condition of the root. Thurston, Hammer and other physio-medical practitioners recommend that only the green root should be used, owing to, rapid deterioration. These herbalists use the fresh root largely in hardening of the liver and reduced biliary flow. 

Therapeutic formulations contain a recombinant form of IFN-a (either interferon alfa-2a or interferon alfa-2b). These are available as powders for reconstitution or as prefilled injection pens. The drug is administered by subcutaneous injection (or intravenous for reconstituted powder formulations) and intramuscular injection. The dosage is usually stated as units per millilitre (refer to BNF for various preparations and dosages). Powder formulations of interferon alfa-2b also contain glycine, sodium phosphate (mono- and dibasic) and human albumin prefilled pens contain sodium chloride, edetate disodium, polysorbate 80 and m-cresol as a preservative. 

Medicinal preparations and dosage forms will occur in carefully controlled doses, e.g. of the order of 2.5-10 mg for benzodiazepines. The dose taken will depend upon the desired effect, the user and a host of other factors. 

Preparations and dosage for injection. Benzylpenicillin may be given i.m. or i.v. (by bolus injection or by continuous infusion). For a sensitive infection, benzylpenicillin 600 mg 6-hourly is enough. This is obviously inconvenient in domi-... 

Part used Seed and fruit peel, although there is evidence that the leaves are equally effective (see comment under Preparation and Dosage). 

The substances have unique properties that show up especially well in pharmacy preparations and dosage forms with sustained release characteristics. For application possibilities see Sect. 18.4.1. The waxy, white and free flowing granules are almost odourless and tasteless and are soluble/miscible in aqueous, organic polar and nonpolar solvents. 

Benzoic acid is soluble in water up to 0.3 %, while the active concentration is 0.1-0.2 %. Benzoic acid also sublimates at higher temperatures and is volatile with water vapour. It is only active in the undissociated form at pH less than 5. Benzoic acid is second-choice preservative in solutions. It works less well than sorbic acid against fungi and yeasts. Benzoic acid in oral preparations and dosage forms is also undesirable for neonates and infants [3]. 

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