Preparation of Polyether Dendrons

The supported dendritic molecules, described thus far, were all based on carbonyl-containing connecting groups (amides, ureas, esters). These groups are vulnerable to a variety of reaction conditions (reductive, hydrolytic, nucleophilic) and, therefore, are unsuitable for a wide range of synthetic and catalytic applications. Moreover, the coordinating nature of the 

DENDRITIC MOLECULES ON SOLID SUPPORT SOLID-PHASE SYNTHESIS AND APPLICATIONS 

SchGmG 15.16. Synthesis of polyether dendrons on solid support by Bradley et al. 

Ethers are chemically and coordinatively more inert than amides. Indeed, Frechet-type polyether dendrimers prepared in solution demonstrate a broad spectrum of chemical and coordinative compatibilities. Accordingly, polyether dendron synthesis on solid support was developed, initially by Bradley and coworkers and later by Portnoy and Dahan Instead of the 3,5-dihydroxy benzyl alcohol derivatives used in the soluble Frechet-type dendrimers, a more SPOS suitable 3,5-bis(hydroxymethyl)phenol unit was conceived as a building block for the dendron construction. 

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