Prenylamine

Chemical Name N-(1 -l /lethvl-2-phenvlethvl)- y-phenvlbenzenepropanamine Common Name — 

Trade Name Manufacturer Country Year Introduced 

Chemical Name N-(2-methylphenyl)-2-(propylamino)-Propanamide hydrochloride Common Name Propitocaine hydrochloride 

One mol of o-bromopropio-ortho-toluidide is mixed with a solution of 3 mols of n-propyl-amine in 500 ml of water-free benzene and the reaction mixture is heated in an autoclave to OO C for 8 hours. After cooling the reaction mixture is treated as described above. The base is obtained as a colorless oil. BP 159°-162 C/0.1 mm. Yield 55%. The base is then converted to the hydrochloride by reaction with HCl. 

Ehrhart, GOtt, H. and Lindner, E. U.S. Patent 3,152,173 October 6,1964 assigned to Farbwerke Hoechst A.G. (Germany) 

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ADR Costartcode Flunarizine diHCI Fluoxetine HCI Mibefradil Nicardipine HCI Pinaverium Bromide Prenylamine Lactate Salt Raloxifene... 

Preliminary studies [241, 249, 250] of the cardiovascular and sympatholytic properties of prenylamine demonstrated that coronary blood flow and oxygenation could be increased under experimental conditions (in dogs) and that the drug interacted in complex fashion with sympathetically innervated organs, but the picture presented was someudiat confused because of the many uncontrolled variables and limitations of the actual techniques used. Anti-arrhythmic activity of potency comparable with that of quinidine, plus local anaesthetic properties, were also demonstrated [251] but the same worker was notable to reproduce these effects in intact live animals with any consistency. Large doses of the drug actually provoked cardiac fibrillation in some cases. 

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