Premenstrual dysphoric disorder fluoxetine

The current SSRIs in the United States inclnde fluoxetine, fluvoxamine, sertraline (Zoloft), paroxetine (Paxil), citalopram (Celexa), and escitalopram (Lexapro). All effectively treat major depression. In addition, one or more of the SSRIs has been shown effective in the treatment of dysthymic disorder, the depressive phase of bipolar disorder, premenstrual dysphoric disorder, panic disorder, social phobia, obsessive-compnlsive disorder, bnlimia nervosa, and binge-eating disorder. 

Premenstrual dysphoric disorder (PMDD) Fluoxetine Sarafem only), paroxetine (controlled-release), sertraline. 

In four instances, the agency has invoked this rule at the time of approval of supplements for new indications for psychotropic drugs already approved for other psychiatric indications. It was noted in the approval letters for these supplements that, since the drugs in question would likely be used in children and/ or adolescents with the newly approved indications, the FDA required the sponsors of these products to conduct studies that would be pertinent to such use in the pediatric population. Since the products were ready for approval in adults, the FDA deferred the required pediatric studies to a future date. Alternatively, sponsors could make an argument for waiver of the requirement. The drug products and indications for which the FDA has required studies under the Pediatric Rule are as follows paroxetine for social anxiety disorder sertraline for post-traumatic stress disorder (PTSD) olanzapine for acute mania in bipolar disorder and fluoxetine in premenstrual dysphoric disorder (PMDD). 

Fluoxetine hydrochloride is most recognized as an antidepressant, but it is also used to relieve symptoms of premenstrual dysphoric disorder (PMDD) (premenstrual syndrome). These symptoms include mood swings, tension, bloating, irritability, and breast tenderness. Eh Lilly began marketing fluoxetine hydrochloride as Sarafem in 2000 for treating PMDD. 

Obsessive compulsive disorder, panic disorder, generalized anxiety disorder, bulimia nervosa, social anxiety disorders, post-traumatic stress disorder, dementia, dysthymia, premature ejaculation. Citalo-pram (investigational) is used for dementia, smoking cessation, ethanol abuse, OCD in children with diabetic neuropathy. Sertraline and Sarafem (contains fluoxetine) are also used to treat premenstrual dysphoric disorder. 

Atmaca M, Kumru S, Tezcan E. Fluoxetine versus V. agnus-castus extract in the treatment of premenstrual dysphoric disorder. Hum Psychopharmacol Clin Exp 2003 18 191-195. 

Cohen, L. S., C. Miner, E. W. Brown, E. Freeman, U. Halbreich, K. Sun-dell, et al. (2002). Premenstrual daily fluoxetine for premenstrual dysphoric disorder a placebo-controlled, clinical trial using computerized diaries. Obstet Gynecol 100(3) 435-44. 

Pearlstein T, Yonkers KA. Review of fluoxetine and its clinical appU-cations in premenstrual dysphoric disorder. Expert Opin Pharmacother 2002 3 979-991. 

Miner C, Brown E, McCray S, et al. Weekly luteal-phase dosing with enteric-coated fluoxetine 90 mg in premenstrual dysphoric disorder A randomized, double-bUnd, placebo-controlled clinical trial. Chn Ther 2002 24 417 33. 

The symptoms of premenstrual syndrome (PMS), also called premenstrual dysphoric disorder, include depressed mood, anxiety, affective lability, and anger or irritability.79 Since low serotonin levels are thought to be involved in the etiology of depression, aggression, and impulsivity,80 specific serotonin reuptake inhibitors have been tested in PMS. The SSRI fluoxetine was found to be better than placebo.81 Since chronic treatment with SSRIs can influence many neuron systems other than serotonin,82 Steinberg et al.83 designed a study using tryptophan, relatively specific for its effect on serotonin, on the effects of symptoms of PMS. In a randomized controlled clinical trial, 37... 

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