Prelog

The Cahn-Ingold-Prelog (CIP) rules stand as the official way to specify chirahty of molecular structures [35, 36] (see also Section 2.8), but can we measure the chirality of a chiral molecule. Can one say that one structure is more chiral than another. These questions are associated in a chemist s mind with some of the experimentally observed properties of chiral compounds. For example, the racemic mixture of one pail of specific enantiomers may be more clearly separated in a given chiral chromatographic system than the racemic mixture of another compound. Or, the difference in pharmacological properties for a particular pair of enantiomers may be greater than for another pair. Or, one chiral compound may rotate the plane of polarized light more than another. Several theoretical quantitative measures of chirality have been developed and have been reviewed elsewhere [37-40]. [Pg.418]

Absolute Stereochemistry Absolute stereochemical assignment of each stereocenter (R vs S) Cahn-Ingold-Prelog Convention (sequence rules)... [Pg.3]

The priority rules in Table 5 1 were developed by R S Cahn and Sir Christopher In gold (England) and Vladimir Prelog (Switzerland) in the context of a different aspect of organic stereochemistry they will appear again in Chapter 7... [Pg.194]

Absolute Configuration According to the Cahn-Ingold-Prelog Notational System... [Pg.291]

The absolute configuration at sulfur is specified by fhe Cahn-Ingold-Prelog mefhod wifh fhe provision fhaf fhe unshared elecfron parr is considered fo be fhe lowesf ranking subsfifuenf... [Pg.314]

A subrule of the Cahn-Ingold-Prelog system specifies that higher mass number takes prece dence over lower when distinguishing between isotopes... [Pg.319]

The Cahn-Ingold-Prelog R-S notation has been extended to chiral allenes and other molecules that have a chiral ity axis Such compounds are so infrequently encountered however we will not cover the rules for specifying their stereochemistry in this text... [Pg.403]

The role of nitronium ion in the nitration of benzene was demonstrated by Sir Christo pher Ingold—the same per son who suggested the SnI and Sn2 mechanisms of nu cleophilic substitution and who collaborated with Cahn and Prelog on the R and S notational system... [Pg.477]

The S in S adenosylmethio nine indicates that the adenosyl group is bonded to sulfur It does not stand for the Cahn-Ingold-Prelog stereochemical descriptor... [Pg.687]

Fischer projections and d-l notation have proved to be so helpful m representing carbohydrate stereochemistry that the chemical and biochemical literature is replete with their use To read that literature you need to be acquainted with these devices as well as the more modern Cahn-Ingold-Prelog R S system... [Pg.1028]

Sequence rule (Section 7 6) Foundation of the Cahn-Ingold-Prelog system It is a procedure for ranking substituents on the basis of atomic number... [Pg.1293]

Cahn-Ingold-Prelog Priority Rules (Table 5 1, p 175)... [Pg.1327]

Absolute Configuration Using Cahn-Ingold-Prelog Notation (Table 7 1, p 269)... [Pg.1327]

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