Pregnenolone 21-chloro

Noninterfering aspirin, ibuprofen, indomethacin, phenylbutazone, pregnenolone, chloro-quine, corticosterone, cortisone, dexamethasone, fluendrenolide, fluocinolone acetonide, fluorometholone, fluprednisolone, hydroxychloroquine, 178-hydroxyprogesterone, mepred-nisone, methylprednisolone acetate, methylprednisolone, paramethasone, prednisolone, prednisone, progesterone, triamcinolone... 

Overall yields of 37% from pregnenolone acetate to 19-norprogesterone and of 43% from 3 -acetoxy-5a-chloro-6l5-hydroxy androstan-17-one to A io)-19-norandrostene-3,17-dioneii have been reported using 6)5,19-ethers as key intermediates. 

The anaesthetic steroid 3a-hydroxy-5a-pregnane-ll,20-dione has normal conformational features, both in the crystal and in solution. X-Ray data show that deoxycholic acid can form an inclusion complex in which alternate molecules of dimethyl sulphoxide and water are held in canals formed by helically arranged host molecules.Six different crystalline forms of 17a-ethynyloestradiol have been recognized. X-Ray structural data are reported for 3-methoxy-2-aza-oestra-l,3,5(10)-trien-17/3-yl acetate, 3/3-hydroxypregn-5-en-20-one (pregnenolone), 5a-cholest-2-ene, 3/3-bromo- and 3/3-chloro-cholest-5-enes, and cholesteryl acetate (at 123 K), benzoate, chloroformate, ° laurate, methyl carbonate, and 24-norcholesteryl acetate. ... 

A number of 2 -acetamido-2 -deoxy-j -D-glucopyranosides of saturated and A -unsaturated C-19 steroids have been prepared by reaction of the steroid 3- or 17-alcohol with the appropriate chloro-sugar, using a mixed mercuric chloride and cyanide catalyst. The A -acetyl-a-glucosaminides of the saturated steroids could be prepared by anomerisation of the -anomer with titanium tetrachloride. The 2 -amino-2 -deoxy-j8-D-glucopyranosides of digitoxigenin, strophanthidin, and pregnenolone have also been prepared. ... 

---