Pregnancy sulfonamides contraindicated

Celecoxib is contraindicated in patients who are allergic to die drug itself, die sulfonamides, odier NSAIDs, or aspirin it also is contraindicated during pregnancy (Category C) and lactation. 

Sulfasalazine is contraindicated in individuals with hypersensitivity to salicylates, sulfonamides, sulfonylureas, and certain diuretics (furosemide, thiazides, and carbonic anhydrase inhibitors). Because it can cause kernicterus, sulfasalazine is contraindicated in infants and children under 2 years of age. Sulfasalazine passes into breast milk and is therefore contraindicated for nursing mothers. Similarly, pregnant women near term should not use this drug, although it appears to be the safest of the DMARDs during early pregnancy. 

Contraindications Anuria, history of hypersensitivity to sulfonamides or thiazide diuretics, renal decompensation, pregnancy... 

Sulfonamides are contraindicated in patients with known hypersensitivity or intolerance to any member of this drug femily. Sulfonamides are also contraindicated in pregnancy at term, for nursing mothers, and for infants less than 2 months old becanse they can promote kernicterus in the newborn by displacing bilirubin from plasma proteins. The sulfonamides, pyrimethamine, and trimethoprim are contraindicated in patients with documented blood dyscrasias. 

Sulfonamide and/or pyrimethamine sensitivity, pregnancy, and G6PD deficiency are contraindications. Use in young infants is considered inadvisable the history of an 8-month-old infant with P. falciparum malaria who developed high fever, tachycardia, hypotension, chills, jaundice, and splenomegaly 48 hours after a single parenteral dose of Fansidar (pyrimethamine + sulfadoxine) (SEDA-16, 309) seems to confirm the wisdom of this advice. It has been advocated that Fansidar should not be used prophylactically if exposure to malaria will last less then 3 weeks, in view of the incidence of severe skin reactions during the first month. 

Like all sulfonamides, sulfasalazine is contraindicated in patients with known hypersensitivity to other drags containing sulfur (thiazides, furosemide, or oral sulfonylureas), in patients with known hypersensitivity to salicylates, in patients with severe renal or hepatic dysfunction, or porphyria, during pregnancy, and during lactation, and in infants and children under age 2. Sulfasalazine is also contraindicated in patients with intestinal or urinary tract obstructions because of the risk of local GI irritation and of crystalluria. 

---