Propionic acidemia pregnancy

Nutrition Management During Pregnancy Maple Syrup Urine Disease, Propionic Acidemia, Methylmalonic Acidemia, and Urea Cycle Disorders... 

There are only two published reports of successful pregnancy in women with propionic acidemia [1,7]. The clinic at the University of Wisconsin-Madison has followed three additional... 

To illustrate these principles, the following are examples of pregnancy in a woman with classical MSUD and a woman with mild propionic acidemia followed at the University of Wisconsin-Madison. 

Case Report 2 Pregnancy In Propionic Acidemia This is the second pregnancy for a 28-year-old woman with mutations in the p-subunit of the propionyl-CoA carboxylase enzyme. She was diagnosed at 4 years of age in a metabolic coma. She has a history of seizures and a cardiac complication of long QT syndrome. As an adult. 

Fig. 21.3 (a)Comparison of energy and protein intake, maternal and birth weight, and carnitine supplementation in two pregnancies in a woman with mild propionic acidemia. (b) Estimated fetal weight (EFW) and abdominal... 

It is unknown if propionic acidemia played a role in the development of preeclampsia for this woman. The other three known pregnancies to women with propionic acidemia delivered at term. In all five pregnancies, there have been no developmental delays or other complications reported in the children. 

Van Calcar SC, et al. Case reports of successful pregnancy in women with maple syrup urine disease and propionic acidemia. Am J Med Genet. 1992 44(5) 641-6. 

---