Pregnancy cobalamins

Frenkel EP, Yardley DA. Clinical and laboratory features and sequelae of deficiency of folic acid (folate) and vitamin Bj (cobalamin) in pregnancy and gynecology. Hematol Oncol Clin North Am 2000 14(5) 1079-100. 

Boneh A, et al. Metabolic treatment of pregnancy and postdelivery period in a patient with cobalamin A disease. Am J Obstet Gynecol. 2002 187(l) 225-6. 

Brunel-Guitton C, et al. Treatment of cobalamin C (cblC) deficiency during pregnancy. J Inherit Metab Dis. 2010 33 Suppl 3 S409-12. 

Folacin deficiency may lead to glossitis, diarrhoea, depression and confusion. Deficiency anaemia may develop especially in pregnancy and in elderly people. Symptoms of deficiency are similar to symptoms of cobalamine deficiency (known as macrocytic anaemia). Megaloblastic anaemia, the most common cause of macrocytic anaemia, is due to a deficiency of either cobalamine or folic acid (or both). Deficiency in the early stages of pregnancy can lead to developmental defects of the foetus (spinal cord defects and incomplete development of the brain). Women who are at increased risk will need increased daily intake of folic acid. 

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