Pregnancy antipsychotic drugs

Antipsychotic drug s are classified as Pregnancy Category C dm (except for clozapine which is Pregnancy Category B). Safe use of these dragp during... 

As noted above, OC failure may lead to accidental pregnancy and exposure of the developing fetus to potentially teratogenic properties of CBZ ( 383). Therefore, OC levels should be closely monitored and patients should notify their physician of spotting, an indicator of OC failure. Prothrombin time and the International Normalized Ratio (INR) should be monitored when patients are on warfarin and CBZ concomitantly. Patients stabilized on an antipsychotic may decompensate when CBZ is added. This may necessitate an increase in the antipsychotic dose and is one indication for TDM of antipsychotic drug levels ( 384). Conversely, when CBZ is discontinued, the dose of these other agents may need to be lowered to avoid toxicity. In summary ... 

All antipsychotic drugs cross the placenta and reach the fetus in potentially significant amounts however, clozapine caused no serious complications or developmental abnormalities during pregnancy in two cases (218). 

Trixler M, Tenyi T. Antipsychotic use in pregnancy. What are the best treatment options Drug Saf 1997 16(6) 403-10. 

Drug interactions other narcotics, antihistamines, benzodiazepines, antipsychotics, antianxiety agents, or other CNS depressants. Use of MAO inhibitors or tricyclic antidepressants can increase the effect of hydrocodone. It is not recommended for pediatric use Pregnancy Category C [1,2,8]. 

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