Pregabalin nausea

Discontinuation Following abrupt or rapid discontinuation of pregabalin, some patients reported symptoms including insomnia, nausea, headache, and diarrhea. Taper pregabalin gradually over a minimum of 1 week rather than discontinuing abruptly. 

Pregabalin should be gradually tapered for a period of at least 1 week abrupt discontinuation may result in insomnia, headache, nausea, and diarrhea... 

Observational studies In 15 patients with familial dysautonomia, pregabalin up to a dose of 6 mg/kg/day gave good results in the treatment of nausea and dysautonomic crises [261 ]. Adverse effects included peripheral edema in one patient who... 

In an open study, 30 children, who had been treated for solid tumors and leukemia and had developed a painful peripheral neuropathy, were given pregabalin 150-300 mg/day for 8 weeks [263 ]. There was significant long-lasting pain relief in 25 them. There were mild or moderate adverse effects nausea and drowsiness in the titration phase) in four patients drug withdrawal was not required. 

Pregabalin and celecoxib, alone and in combination, have been evaluated in the treatment of chronic low-back pain in 36 patients in a 12-week, randomized, crossover study [267 ]. The combination was more effective than either monotherapy. Adverse effects were recorded in 16 patients and four patients withdrew as a result. Five patients reported nausea or dizziness during treatment with pregabalin and seven had similar symptoms during treatment with celecoxib -I- pregabalin. 

Of 20 patients with essential tremor who were randomized to pregabalin 150-600 mg/day or placebo in a double-blind, crossover study four withdrew during pregabalin treatment because of postural instability, nausea, and dizziness (two cases) [269 ]. Other adverse effects were mild to moderate in intensity. More common during pregabalin versus placebo were drowsiness (pregabalin 5 versus placebo 3), dizziness (4 versus 1), and fatigue (3 versus 0). 

Tramadol 100 mg/day has been compared with ibuprofen and pregabalin in 20 healthy volunteers [173 ]. Tramadol was associated with mild adverse effects, mainly fatigue/drowsiness (eight episodes), nausea/ vomiting (seven), dizziness/headache/dijfi-culty in concentrating (seven). The NNTh for tramadol was 1.6. 

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