Prefrontal cortex modulation

Lorrain DS, Baccei CS, Bristow LJ, Anderson JJ, Varney MA. 2003. Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex Modulation by a group II selective metabotropic glutamate receptor agonist LY379268. Neuroscience 117 697-706. 

EEG slow waves. The differential EEG and ACh responses to dialysis delivery of AF-DX 116 (M2/M4) versus pirenzepine (M1/M4) supports the conclusion that, in B6 mouse, postsynaptic muscarinic receptors of the Ml subtype form one receptor mechanism by which ACh activates the EEG (Douglas et al, 2002a). The data summarized in Fig. 5.11 provide direct measures of G protein activation in basal forebrain and prefrontal cortex by muscarinic cholinergic receptors (DeMarco et al, 2004). The in vitro data of Fig. 5.11A indicate the presence of functional muscarinic receptors in regions of B6 mouse prefrontal cortex where in vivo microdialysis studies (Douglas et al, 2002a, b) revealed modulation of ACh release and EEG by pre- and postsynaptic muscarinic receptors (Figs. 5.9 and 5.10). 

Douglas, C. L., Baghdoyan, H. A. Lydic, R. (2001). M2 muscarinic autoreceptors modulate acetylcholine release in prefrontal cortex of C57BL/6J mouse. 

Middleton, L.S., Cass, W.A., and Dwoskin, L.P., Nicotinic receptor modulation of dopamine transporter function in rat striatum and medial prefrontal cortex, J. Pharmacol. Exp. Then, 308, 367, 2003. 

Vidal C, Changeux JP. (1993). Nicotinic and muscarinic modulations of excitatory synaptic transmission in the rat prefrontal cortex in vitro. Neuroscience. 56(1) 23-32. 

Taber MT, Fibiger HC. 1995. Electrical stimulation of the prefrontal cortex increases dopamine release in the nucleus accumbens of the rat modulation by metabotropic glutamate receptors. J Neurosci 15(5 Pt 2) 3896-3904. 

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