Prediction techniques threaded structures

Threading techniques try to match a target sequence on a library of known 3D structures by threading the target sequence over the known coordinates. In this manner, threading tries to predict the 3D structure starting from a given protein sequence. It is sometimes successful when comparisons based on sequences or sequence profiles alone fail due to a too low sequence similarity. 

The most robust of the structure prediction techniques is homology model building or threading (Bryant and Lawrence, 1993 Fetrow and Bryant, 1993 Jones and Thornton, 1996). The threading methods search for structures that have a similar... 

Lemer, C. M., Rooman, M. J., and Wodak, S. J. (1995). Protein structure prediction by threading methods Evaluation of current techniques. Proteins 23, 337-355. 

More distantly related structures can be modeled by the use of the process of threading. This is a computational technique by which the sequence of the protein of an unknown structure is threaded through a nom-edun-dant library of well-determined structures to determine which are compatible with the sequence. Basic statistical methods for predicting secondary structure, a helix and p sheet, have 80% veracity. 

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