Prazosin Alcohol

Polyvinyl alcohol with povidone and chlorbutanol eye drops Prazosin Prednicarbate... 

ALCOHOL ANTI HYPERTENSIVES AND HEART FAILURE DRUGS, e.g. PRAZOSIN 1. Acute alcohol ingestion may t hypotensive effects 2. Chronic moderate or heavy drinking 1 hypotensive effects 1. Additive hypotensive effect 2. Chronic alcohol excess is associated with hypertension Monitor BP closely as unpredictable responses can occur. Advise patients to drink alcohol only in moderation and to avoid large variations in the amount of alcohol drunk... 

In a well-controlled study in 10 Japanese patients with mild hypertension, the blood pressure reduction caused by alcohol 1 ml/kg was significantly increased by concurrent treatment with prazosin 1 mg tds (5). At 2-4 hours after ingestion the blood pressure fell by 18/12 mmHg without prazosin and by 24/18 mmHg with prazosin. These results raise the possibility that heavy drinking may cause symptomatic hjrpotension in patients taking prazosin. 

The plasma levels of both indoramin and alcohol may be raised by concurrent use. The combination of alcohol and indoramin has been reported to increase drowsiness, which may possibly increase the risks when driving or using machinery. Prazosin appears to enhance the hypotensive effects of alcohol. 

Information is limited but the interaction between indoramin and alcohol appears to be established. The clinical importance of the raised levels of both drugs is uncertain. However since indoramin sometimes causes drowsiness when it is first given, there is the possibility that alertness will be reduced, which could increase the risks of driving or handling machinery. Patients should be warned. Prazosin appears to enhance the hypotensive effect of alcohol, see also, Alcohol + Antihypertensives , p.48. 

A study in 40 men with essential hypertension (taking beta blockers, cap-topril, diuretics, methyidopa, prazosin or verapamil) who were moderate to heavy drinkers, found that when they reduced their drinking over a 6-week period from an average of 450 mL of alcohol weekly (about 6 drinks daily) to 64 mL of alcohol weekly, their average blood pressure fell by 5/3 mrnHg. The reasons for this effect are uncertain. 

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