Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Pravastatin sodium

Figure 13 Purification of pravastatin sodium by preparative liquid chromatography. Reprinted from [12], copyright 2001, with permission from Elsevier. (Column 125 X 4.6 mm i.d. 3 pm Hypersil ODS mobile-phase gradient methanol water triethylamine acetic acid 45 54.8 0.1 0.1 for 13 min, to 99.8 0 0.1 0.1 over 9 min flow rate 1.2 ml/min detector UV 235 nm.)... Figure 13 Purification of pravastatin sodium by preparative liquid chromatography. Reprinted from [12], copyright 2001, with permission from Elsevier. (Column 125 X 4.6 mm i.d. 3 pm Hypersil ODS mobile-phase gradient methanol water triethylamine acetic acid 45 54.8 0.1 0.1 for 13 min, to 99.8 0 0.1 0.1 over 9 min flow rate 1.2 ml/min detector UV 235 nm.)...
Figure 1.6 ICH Class 2 solvents measured using GC. Purification of pravastatin sodium by preparative liquid chromatography. Reprinted from [15], copyright 2004, with permission from Elsevier. (Column 30 m X 0.53 mm i.d. 3 pm OVI-G43 (Supelco) carrier gas helium at 5 ml/min injection in split mode total flow 25 ml/min injector temperature 140 C flame ionization detector temperature 25C C and oven temperature 40°C for 20 min, to 240°C at 10°C/min, maintain at 240 C for 20 min. The components are 1 methanol, 3 acetonitrile, 4 dichloromethane, 5 hexane, 6 cw-l,2-dichloroeth-ylene, 7 nitromethane, 8 chloroform, 9 cyclohexane, 13 1,2-dimethoxyethane, 15 1,1,2-trichloroethyl-ene, 16 methylcyclohexane, 17 1,4-dioxane, 18 pyridine, 19 toluene, 20 2-hexanone, 21 chlorobenzene, 22 ethylbenzene, 23 m-xylene, 24p-xylene, 25 o-xylene, and 26 tetralin. The solvents are dissolved in DMF and heated at 80X for 60 min, and a sample of the headspace is injected.)... Figure 1.6 ICH Class 2 solvents measured using GC. Purification of pravastatin sodium by preparative liquid chromatography. Reprinted from [15], copyright 2004, with permission from Elsevier. (Column 30 m X 0.53 mm i.d. 3 pm OVI-G43 (Supelco) carrier gas helium at 5 ml/min injection in split mode total flow 25 ml/min injector temperature 140 C flame ionization detector temperature 25C C and oven temperature 40°C for 20 min, to 240°C at 10°C/min, maintain at 240 C for 20 min. The components are 1 methanol, 3 acetonitrile, 4 dichloromethane, 5 hexane, 6 cw-l,2-dichloroeth-ylene, 7 nitromethane, 8 chloroform, 9 cyclohexane, 13 1,2-dimethoxyethane, 15 1,1,2-trichloroethyl-ene, 16 methylcyclohexane, 17 1,4-dioxane, 18 pyridine, 19 toluene, 20 2-hexanone, 21 chlorobenzene, 22 ethylbenzene, 23 m-xylene, 24p-xylene, 25 o-xylene, and 26 tetralin. The solvents are dissolved in DMF and heated at 80X for 60 min, and a sample of the headspace is injected.)...
PRAVASTATIN SODIUM Pravastatin can be administered as a single dose at any time of the day, with or without food. Because the maximal effect of a given dose is seen within 4 weeks, perform periodic lipid determinations at this time and adjust dosage according to the patient s response to therapy and established treatment guidelines. [Pg.613]

Hydroxy-3-Methylgluteryl (HMG)-CoA reductase inhibitors atorvastatin calcium fluvastatin sodium lovastatin pravastatin sodium simvastatin... [Pg.602]

Pravastatin sodium besides increasing LDL cholesterol catabolism, also inhibits LDL-cholesterol production by inhibiting hepatic synthesis of VLDL-cholesterol, the LDL-cholesterol precursor. These effects result in a reduction of total cholesterol, LDL-cholesterol, VLDL-cholesterol, apolipoprotein B and trigly-cerides, whilst increasing (HDL-cholesterol) and apolipoprotein A. It has little effect on cholesterol synthesis in other tissues. [Pg.197]

Batey RG, Harvey M. Cholestasis associated with the use of pravastatin sodium. Med J Aust 2002 176(11) 561. [Pg.566]

Pravastatin (47) and Mevastatin (48) are anticholesterol drugs which act by competitively inhibiting HMG Co A reductase [75], Pravastatin sodium is produced by two fermentation steps. The first step is the production of compound ML-236B by Penicillium citrinum [75-77], The purified compound was con-... [Pg.159]

T Matsuoka, S Miyakoshi, K Tanzawa, K Nakahara, M Hosobuchi, N Serizawa. Purification and characterization of cytochrome P-450sca from Streptomyces car-bophilus. ML-236B (compactin) induces a cytochrome-P450sca in Streptomyces carbophilus that hydroxylates ML-236 B to pravastatin sodium (CS-514), a tissue-selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Eur J Bio-chem 184 707-713, 1989. [Pg.171]

Common Name Eptastation sodium Pravastatin sodium Structural Formula ... [Pg.2821]

CS 514 SQ 31000 Pravachol ) is isolated from Absidia coerulea, and is a hmg-COA REDUCTASE INHIBITOR. It is used as an antihypercholesterolaemic agent, pravastatin sodium pravastatin. [Pg.230]

Kaesemeyer WH, Caldwell RB, Huang J, Caldwell RW. 1999. Pravastatin sodium activates endothelial nitric oxide synthase independent of its cholesterollowering actions. J. Am. Coll. Cardiol. 33 234 11... [Pg.121]

Singhvi SM, Pan HY, Morrison RA, Willard DA (1990) Disposition of pravastatin sodium, a tissue-selective HMG-CoA reductase inhibitor, in healthy subjects. Br J Clin Pharmacol 29 239-243... [Pg.86]

DW Everett, TJ Chando, GC Didonato, SM Singhvi, HY Pan, SH Weinstein. Biotransformation of pravastatin sodium in humans. Drug Metab Dispos 19 740, 1991. [Pg.190]

C Dumouseaux, S Muramatsu, W Takasaki et al. Highly sensitive and specific determination of pravastatin sodium in plasma by high-performance liquid chromatography and laser-induced fluorescence detection after immobilized antibody extraction. J Pharm Sci 83 1630, 1994. [Pg.306]

Phosphoric acid, isooclyl ester. 81131 -70-6 Pravastatin sodium 3144... [Pg.751]

See other pages where Pravastatin sodium is mentioned: [Pg.755]    [Pg.63]    [Pg.100]    [Pg.10]    [Pg.609]    [Pg.1016]    [Pg.247]    [Pg.160]    [Pg.160]    [Pg.2820]    [Pg.2820]    [Pg.2821]    [Pg.2822]    [Pg.1298]    [Pg.1760]    [Pg.230]    [Pg.312]    [Pg.757]    [Pg.580]    [Pg.580]    [Pg.1222]    [Pg.1222]    [Pg.516]    [Pg.516]   
See also in sourсe #XX -- [ Pg.1016 ]

See also in sourсe #XX -- [ Pg.299 ]

See also in sourсe #XX -- [ Pg.580 , Pg.581 ]

See also in sourсe #XX -- [ Pg.378 ]



SEARCH



Pravachol - Pravastatin sodium

Pravastatin

© 2024 chempedia.info