Probucol Pravastatin

Hence we study the level of LDL lipoperoxides in patients with atherosclerosis who had been for a long-time treated with HMG-CoA-reductase inhibitors in monotherapy as well as in combination with natural or synthetic antioxidants such as ubiquinon Qio and probucol in double-blind placebo cmitrolled trials [36,37]. The treatment of patients with inhibitor of cholesterol and ubiquinon Qio biosynthesis pravastatine alone in daily dose 40 mg during 6 months was followed by accumulation of LDL lipohydropooxides in the blood plasma [36] (Figure 17). On the other hand the 6 months administration of the same dose of pravastatine in combination with natural antioxidant ubiquinon Qw in daily dose 60 mg sharply decreased even initial LDL lipoperoxides level in the plasma of patients [36] (Figure 17). 

In one of our other studies [37], the 6 months therapy with 0,4 mg daily of other HMG-CoA-reductase inhibitor cerivastatin, which is more effective than pravastatin as cholesterol-lowering drug, sharply increased the level of LDL lipohydroperoxides in the blood plasma of patients [37] (Figure 18). At the same time administration of cerivastatin in combination with synthetic antioxidant probucol in daily dose 250 mg did not produce the increase of the LDL lipohydroperoxide level in the plasma during all time of the observation [37] (Figure 18). 

ER Squibb. A report on die bioavailability of pravastatin in die presence and absence of gemfibrozil or probucol in healthy male subjects. Data on fQe (Protocol No 27, 201-18), 1988. 

Probucol 500 mg did not cause any clinically significant changes in the bioavailability of a single 20-mg dose of pravastatin in a study in 20 healthy subjects. ... 

The inhibitory effects of 5-hydroxyfluvastain (me-tabohte 2 of fluvastain) and 6-hydroxyfluvastain (metabohte 3 of fluvastain) on the formation of O2, Oa , HO, and OCT were stronger than that of pravastatin, simvastatin, probucol and a-tocopherol (Nakashima et al. 2001). Scavenging of O2 by the des-isopropyl metabohtes 4 and 5 of fluvastain, (-1-)-fluvastain and (-)-fluvastain was also noted. 

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