PPARy ligand domain

Figure 1A A portion of the X-ray structure (205) cf rosiglitazone co-crystallized with the PPARy ligand-binding domain (LED) and a fragment of the coactivator protein SRC-1, showing the bound con-fo rmation of rosiglitazone. Coordinates were obtained from the Protein Data Bank (212) and displayed with RasMol.

Nolte et al. [59] solved the X-ray crystal structure of the hiunan PPARy ligand-binding domain (LBD) with rosightazone (PDB 2PRG) at a resolution of 2.2 A which revealed a large binding pocket that explained diversity of... 

Uppenberg, J., Svensson, C., Jaki, M., Bertilsson, G., Jendeberg, L., and Berken-stam, A. (1998). Crystal Structure of the Ligand Binding Domain of the Human Nuclear Receptor PPARy./ Biol. Chem. 273, 31108-31112. 

Figure 14.4 Superposed X-ray structures of the ligand-binding domains of ERpS, PPARy, and FXR, each with bound ligand. ER(3 with genistein (41, blue), PPARy with rosiglitazone (red), FXR with 50 (yellow).

Fig. 20 Ligand (Rosiglitazone)-enzyme (PPARy) crystal structure where the ligand is shown in the binding domain of PPARy (Reprinted with permission from [151], Copyright 2001 Elsevier Science Inc.)...

A GRID/CPCA analysis of the three subtypes of Peroxisome Proliferator-Activated Receptors (PPARs) vas reported by Pirard [18] using three PPARa, eight PPARy, and three PPARd X-ray structures of the ligand binding domain (LED). 

Scheme 1 Schematic diagram showing the binding modes of PPARy agonists in the ligand binding domain...

The molecular modeling studies of oximes having 5-benzyl-2,4-thiazolidines-moities (Fig. 8), ligand binding domain of PPARy were reported by Iwata... 

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