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Potency-weighted mean

IC50 Drug potency WTmale Mean weight for males... [Pg.890]

As mentioned above, drug potency is a body weight independent parameter, and it should be the same across species. Therefore, Vk2 obtained from a mouse model can be used to predict the total AUC during the mean tumor growth time in humans. It was demonstrated that Vk2 obtained from human tumor xenografts in nude mice correlates to total AUC in a three-week cycle in human for 10 anticancer agents at their average therapeutic dose [55],... [Pg.94]

T Assay/Inspection, Potency, Degradion Products, Preservative Assay, pH, Dissolution, Weight change. Redispersibility (suspension only). Mean size and Distribution of Particles (as appropriate) X X-ray powder diffraction. Test first lot C Chiral assay. Test first lot... [Pg.314]

It is not possible to determine a value of C to be used in all cases. The value of C depends on the total statistical weight of the study (the reciprocal of the variance of logio estimates of relative potency, from which the mean relative potency is obtained), i.e. ... [Pg.435]

See other pages where Potency-weighted mean is mentioned: [Pg.137]    [Pg.137]    [Pg.930]    [Pg.251]    [Pg.109]    [Pg.151]    [Pg.508]    [Pg.444]    [Pg.144]    [Pg.35]    [Pg.55]    [Pg.388]    [Pg.311]    [Pg.100]    [Pg.119]    [Pg.86]    [Pg.94]    [Pg.64]    [Pg.210]    [Pg.148]    [Pg.881]    [Pg.588]    [Pg.64]    [Pg.2281]    [Pg.250]    [Pg.523]    [Pg.18]    [Pg.526]    [Pg.72]    [Pg.346]    [Pg.374]    [Pg.185]    [Pg.250]    [Pg.523]    [Pg.26]    [Pg.236]    [Pg.23]    [Pg.28]    [Pg.23]    [Pg.421]    [Pg.413]    [Pg.335]    [Pg.972]   
See also in sourсe #XX -- [ Pg.137 ]



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Potency

Weighted mean

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