Postprandial duodenal

Flour 13 Postprandial duodenal pH in 6 healthy controls (solid line) and 6 patients with chronic pancreatic Insufficiency (broken line). Ban show mean SEM , p< 0.05. (From Ref. 61.)... 

Hamlet A, Olbe L (1996) The influence of Helicobacter pylori infection on postprandial duodenal acid load and duodenal bulb pH in humans. Gastroenterology 111 391-400... 

Gastroesophageal reflux. Reflux of the stomach and duodenal contents into the esophagus, which may sometimes occur normally, particularly in the distended stomach postprandially, or as a chronic pathological condition. Gastroesophageal. Pertaining to the stomach and esophagus, as the gastroesophageal junction. 

To restore nutrient digestion in exocrine pancreatic insufficiency, sufficient enzymatic activity must be administered into the duodenal lumen simultaneously with meal substrates. Intraluminal lipid digestion in postprandial chyme requires lipase activity of at least 40-60 IU/mL throughout the digestive period, which translates into 25,000 to 40,000 IU intraduodenal lipase for digestion of a regular meal. Because plain enzyme preparations undergo rapid lipase inactivation due to acid and proteolytic destruction, it is necessary to administer up to 10-fold more lipase orally to achieve these quantities within the duodenum. 

Superior mesenteric artery (SMA) syndrome is an uncommon but well recognized clinical entity characterized by compression of the third, or transverse, portion of the duodenum against the aorta by the SMA, resulting in chronic, intermittent or acute complete or partial duodenal obstruction. Clinical symptoms are chronic upper abdominal symptoms such as epigastric pain, nausea, vomiting (bilious or partially digested food), postprandial discomfort and sometimes subacute small bowel obstruction. The stomach can be massively dilated and perforation has been described (Carty et al. 2005 Parker 2003). 

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