Positive for point/gene mutation

Positive for Point/Gene Mutation and DNA Damage In Pro- and/or Eukaryotic Systems... 

All these techniques create genetic diversity by recombination and point mutations and are well developed. However, insertions and deletions (indels) are also important types of mutation which are probably underrepresented in many conventional mutagenesis strategies. Methods for incorporation of indels in predefined positions in a combinatorial manner have been developed.Although there are some published studies on their use in the directed evolution of biocatalysts,the full potential of these newer methods of gene mutation for enzyme improvement are yet to be demonstrated. 

A positive response in the mouse heritable translocation test indicates that exposure to the test substance results in an increase in the number of translocations observed for at least one test point, or an increase in the number of translocations observed, as a result of heritable gene mutations. 

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