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Position effect, gene silencing

Position effect, gene silencing No effects Variable, decreased transgene expression... [Pg.60]

Regulatory regions are transcriptional control sequences, which consist of promoters, response elements, enhancers and possibly silencers, located upstream of the start site of transcription. The overall effect on gene transcription is a sum of the contributions of these elements and the activities of proteins recruited to these sites. Promoters are located immediately upstream of the start site and initiate transcription. They often contain tissue- or cell-specific elements if the gene is not ubiquitously expressed. Enhancers are positive regulatory elements which function independently of orientation and distance from the genes they regulate. [Pg.1064]

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Gene silencer

Gene silencing

Position effect

Positive Effects

Silence

Silenced genes

Silencers

Silencing

Silencing effects

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