Polystyrene sulfonate Antacids

Sodium Polystyrene Sulfonate (Kayexalate) [Potassium Removing Resin] Uses Rx of T K Action NaVK" ion-exchange resin Dose Adults. 15-60 g PO or 30-60 g PR q6h based on serum Peds. 1 g/kg/dose PO or PR q6h based on serum (given w/ agent, eg, sorbitol, to promote movement through the bowel) Caution [C, M] Contra T Na" Disp Powder, susp SE T Na", -i Na retention, GI upset, fecal impaction Interactions T Risk of systemic alkalosis W/ Ca- or Mg-containing antacids EMS Monitor ECG for h5 pokalemia (flattened T waves) OD Not systemically absorbed but may cause h5 pokalemia and the associated effects (muscle weakness, confusion) and bowel obstruction s5rmpto-matic and supportive... 

Sodium polystyrene sulfonate [NE] Binds antacid cation in gut, resulting in metabolic alkalosis. 

Cation-containing antacids and laxatives (for example magnesium hydroxide, calcium carbonate) can reduce the effect of polystyrene sulfonate and metabolic acidosis can develop. This has been reported in both children (9,10) and adults. 

The concurrent use of antacids with sodium polystyrene sulfonate can result in metabolic alkalosis. Use with aluminium hydroxide has resulted in intestinal obstruction. 

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