Polysaccharides of pathogenic bacteria

Varying proportions of D-mannose and of the rarely occurring D-form of arabinose are obtained on hydrolysis of the polysaccharide of tubercle bacillus Mycobacterium tuberculosis) strain H-37, whereas the poly- 

Polysaccharides of Corynebacterium diphtheriae yield D-galactose, pentoses and amino sugars on hydrolysis. n-Glucose and D-mannose are major hydrolytic products of the polysaccharide of Clostridium perfringens. Complete hydrolysis of the polysaccharide of the anthrax bacillus yielded acetyl-n-glucosamine and D-galactose. 

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These protruding structures may form catalytic sites or binding sites for small molecules. Remarkably, some polysaccharide modification enzymes of pathogenic bacteria are similar to enzymes of their host cells. For example, during cell development, pectin, a principal component in the primary cell wall of plants, is modified by its own pectin methylesterases that have /1-solenoid structures (Johansson et al, 2002) and in this respect, resemble pectin lyases secreted by bacteria to break down these structures (Lietzke et al., 1996). 

In this lecture I will characterize capsular polysaccharides of coli bacteria which cause extraintestinal diseases, such as pyelonephritis. To put these studies into perspective, the main pathogenic mechanisms of Escherichia coli, and the role of capsules will first be discussed briefly. 

Glucuronic acid is also constituent of pathogenic bacteria. The simplest structure for a pneumococcal capsular polysaccharide has the repeating unit [- 4)-/3-d-G1c-(1 3)-/3-D-GlcpA-(l ]ra.120... 

Antimicrobial defenses in most plants, on the other hand, have been shown to result from a post-challenge response of the plant elicited by the pathogen through products associated with the invading organism. Such products are extra-cellular polysaccharides of bacteria, or the 3-qlucans of Phytophthora mycellial walls (2). 

H. J. Jennings Structure, conformation and immunology of the polysaccharide capsules of human pathogenic bacteria... 

Adult-animal sera contain antibodies to a variety of polysaccharides, including those of human pathogenic bacteria, indicating that, to confer immunity, disease is not required. Robbins and coworkers7 212 were able to detect antibodies having a specificity for Vibrio cholerae... 

That Cross-react with the Polysaccharide Capsules of Human Pathogenic Bacteria... 

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