Polysaccharides, chiral recognition cellulose esters

Among optically active polymers, polysaccharide derivatives are particularly valuable. Polysaccharides such as cellulose and amylose are the most readily available optically active polymers and have stereoregular sequences. Although the chiral recognition abilities of native polysaccharides are not remarkable, they can be readily converted to the esters and carbamates with high chiral recognition abilities. The chiral recognition mechanism of these derivatives has been clarified to some extent. 

Polysaccharides, such as cellulose and amylose (Fig. 10), are the most abundant polymers on the earth and are known to have a chiral recognition ability. In 1951, Kotake resolved some amino acid derivatives by paper chromatography [35], However, their abilities and mechanical properties are not adequate for use as CSPs in HPLC. Fortunately, polysaccharides are readily modified to esters and carbamates by the reaction with acid chlorides and isocyanates, respectively, and these derivatives show very attractive chiral recognitiOTis based on their helical conformations. 

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