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Polyplexes bioresponsive

Takae S, Miyata K, Oba M, Ishii T, Nishiyama N, Itaka K, Yamasaki Y, Koyama H, Kataoka K (2008) PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors. J Am Chem Soc 130 6001-6009... [Pg.23]

The following sections discuss how polymers and polyplexes can be chemically designed to be bioresponsive in three key delivery functions (1) polyplex surface shielding, (2) interaction with lipid bilayers, and (3) polyplex stability. [Pg.10]

Fig. 1 Bioresponsive polyplexes. (a) Systemic circulation of shielded polyplexes in blood stream and attachment to cell surface receptor (b) endocytosis into endosomes, deshielding by cleavage of PEG linkers and activation of membrane-destabilizing component by acidic pH or other means (c) endosomal escape into cytosol (d) siRNA transfer to form a cytosolic RNA-induced silencing complex complex (e) cytosolic migration and intranuclear import of pDNA (/) presentation of pDNA in accessible form to the transcription machinery... Fig. 1 Bioresponsive polyplexes. (a) Systemic circulation of shielded polyplexes in blood stream and attachment to cell surface receptor (b) endocytosis into endosomes, deshielding by cleavage of PEG linkers and activation of membrane-destabilizing component by acidic pH or other means (c) endosomal escape into cytosol (d) siRNA transfer to form a cytosolic RNA-induced silencing complex complex (e) cytosolic migration and intranuclear import of pDNA (/) presentation of pDNA in accessible form to the transcription machinery...
Bioresponsive Polyplex Shielding and Endosomal Escape 3.1 Reversible Polyplex Shielding... [Pg.231]

See other pages where Polyplexes bioresponsive is mentioned: [Pg.9]    [Pg.11]    [Pg.11]    [Pg.13]    [Pg.14]    [Pg.227]    [Pg.229]    [Pg.147]    [Pg.500]    [Pg.130]    [Pg.164]    [Pg.165]    [Pg.165]    [Pg.166]    [Pg.167]   
See also in sourсe #XX -- [ Pg.7 , Pg.164 ]

See also in sourсe #XX -- [ Pg.7 , Pg.164 ]



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