Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Polyplexes shielding, bioresponsive

Bioresponsive Polyplex Shielding and Endosomal Escape 3.1 Reversible Polyplex Shielding... [Pg.231]

The following sections discuss how polymers and polyplexes can be chemically designed to be bioresponsive in three key delivery functions (1) polyplex surface shielding, (2) interaction with lipid bilayers, and (3) polyplex stability. [Pg.10]

Fig. 1 Bioresponsive polyplexes. (a) Systemic circulation of shielded polyplexes in blood stream and attachment to cell surface receptor (b) endocytosis into endosomes, deshielding by cleavage of PEG linkers and activation of membrane-destabilizing component by acidic pH or other means (c) endosomal escape into cytosol (d) siRNA transfer to form a cytosolic RNA-induced silencing complex complex (e) cytosolic migration and intranuclear import of pDNA (/) presentation of pDNA in accessible form to the transcription machinery... Fig. 1 Bioresponsive polyplexes. (a) Systemic circulation of shielded polyplexes in blood stream and attachment to cell surface receptor (b) endocytosis into endosomes, deshielding by cleavage of PEG linkers and activation of membrane-destabilizing component by acidic pH or other means (c) endosomal escape into cytosol (d) siRNA transfer to form a cytosolic RNA-induced silencing complex complex (e) cytosolic migration and intranuclear import of pDNA (/) presentation of pDNA in accessible form to the transcription machinery...
See other pages where Polyplexes shielding, bioresponsive is mentioned: [Pg.11]    [Pg.227]    [Pg.11]    [Pg.147]    [Pg.165]    [Pg.166]    [Pg.167]   
See also in sourсe #XX -- [ Pg.10 ]



SEARCH



Bioresponses

Bioresponsive Polyplex Shielding

Bioresponsive Polyplex Shielding

Bioresponsivity

Polyplex

Polyplexes

Polyplexes shielding

© 2024 chempedia.info