Polymethacrylate-type monoliths

Moreover, in-situ copolymerization approaches of polymerizable chiral cin-chonan carbamate selectors have also been shown to be viable straightforward routes to enantioselective separation media. In one approach, polymethacrylate-type monoliths have been fabricated by copolymerization of functional monomers and crosslinker in presence of porogenic solvents [80-85]. They have been utilized mainly for CEC (and will be described in detail later) while they turned out to be less suitable for HPLC application because of a low crosslinking degree. 

In one approach, polymethacrylate-type monoliths have been fabricated by copolymerization of the chiral monomer 0-9-[2-(methacryloyloxy)ethylcarbamoyl]-10,11-dihydroquinidine 1 or 0-9-(tert-butylcarbamoyl)-ll-[2-(methacryloyloxy) ethylthio]-10,ll-dihydroquinine 2 (see Figure 1.34a), the comonomer 2-hydroxyethylmethacrylate (HEMA), the crosslinker ethylenedimethacrylate (EDMA) in presence of the binary porogenic solvent mixture cyclohexanol and 1-dodecanol, directly in a single step within fused-silica capillaries. Initiation of the polymerization by either thermal treatment or UV irradiation yielded microglobular polymer morphologies, such as those well known from their corresponding nonchiral... 

Three main types of polymer-based monoliths are polymethacrylate-based monoliths where methacrylate forms the major component of the monomers for polymerization, polyacrylamide-based monoliths where cross-linked polyacrylamide is synthesized directly within the capillary, and polystyrene-based monoliths that are usually prepared from styrene and 4-(chloromethyl) styrene as monomers and divinylbenzene (DVB) as the cross-linker. 

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