Polymerizable drug derivatives

A number of examples of the synthesis of polymerizable drug derivatives have been reported which are beyond the scope of this article. Hovrever, it should be borne in mind that in most cases, simply the introduction of the polymerizable group into a drug molecule is not sufficient to produce a biologically active drug conjugate. The drug must be separated from the polymer chain by a spacer and practically this may turn out to be a difficult synthetic operation. 

Polymerizable derivatives of an antidiabetic drug, JV-(4-amino-benzenesulfonyl)-JV -urea, where the active substance is bound to a methacrylate moiety via spacers of various lengths containing amide or urethane links were synthesized and copolymerized with HPMA [142]. 

Several comprehensive reviews on polymerizable lipids and supramolecular structures derived from them appeared between 1985 and 2002 [3,25-31], Consequently, this review focuses on developments in this field during 2000-2008. These include synthesis of new types of polymerizable lipids, creation and characterization of novel poly(lipid) membrane systems, and applications of polymerized vesicles and membranes in chemical sensing, separations science, drug delivery, materials biocompatibility, and other fields. 

Hofmann et al. prepared a polymerizable derivative of streptomycine sulfate (Str—CH=0) by reacting the aldehyde group of the drug with methacrylic acid hydrazide... 

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