Polymeric implants reservoir-type

Figure 4.3 The steady-state concentration profile of a drug in a reservoir-type polymeric implant Cr=concentration of drug in the reservoir, concentration of drug at the site of implantation...

Figure 4.4 M t Zero-order controlled release profile of a reservoir-type nondegradable polymeric implant (porous or compact membrane)...

Reservoir/matrix hybrid-type non-degradable polymeric implants are also available. Such systems are designed in an attempt to improve the M t1/2" release kinetics of a matrix system, so that release approximates the zero-order release rate of a reservoir device. Examples of these types of systems include ... 

Reservoir/matrix hybrid-type polymeric implants... 

A company is trying to develop a reservoir-type polymeric implant for the controlled release of estradiol for 3 months. Which techniques would you recommend to the company to increase the drag release rate ... 

What is the main reason for developing a reservoir/matrix hybrid-type polymeric implant ... 

Which polymer is most extensively used as non-degradable nonporous membrane to develop reservoir-type polymeric implants ... 

The design of biodegradable implant devices based on PLA and PGA, noted earlier, have been mainly limited to reservoir types where the drug, in suspension or crystalline state, is sealed within a polymeric capsule so that the rate of release is regulated by diffusion characteristics. Another approach involves the use of poly(a-amino acids) in which the drug is encapsulated in polymeric shells, intermixed with the polymer, or covalently bound to the polymer backbone. i- ... 

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