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Polymeric drug cleavability

Figure 10.4 Structures of polymers and polymeric drug delivery systems sensitive to light and electric fields, (a) Light-sensitive polyamidoamine dendrimes conjugated with doxorubicin via photo-cleavable ortho-nitrobenxyl linkages (Choi et al., 2010). (b) Electric-field-sensitive (Wood et al., 2008). Figure 10.4 Structures of polymers and polymeric drug delivery systems sensitive to light and electric fields, (a) Light-sensitive polyamidoamine dendrimes conjugated with doxorubicin via photo-cleavable ortho-nitrobenxyl linkages (Choi et al., 2010). (b) Electric-field-sensitive (Wood et al., 2008).
Figure 2.11 pH-sensitive polymeric vesicles from the coassembly of amphiphilic PLL-CA and the acid-cleavable polymer-drug conjugate. Reproduced with permission from L. Zhu, L. Zhao, X. Qu and Z. Yang, Langmuir, 2012, 28, 33, 11988. 2012, American Chemical Society [57]... [Pg.50]

Chan, Y. Bulmus, V. Zareie, M.H. Byrne, F.L. Barner, L. Kavallaris, M. Acid-cleavable polymeric core-shell particles for delivery of hydrophobic drugs. J. Control. Release 2006,115 (2), 197—207. [Pg.1307]

Acid-cleavable DOX-loaded biodegradable polymeric micelles were also made by copolymerization of BMDO and l,2 3,4-di-O-isopropylidene-6-O-(20-formyl-40-vmylphenyl)-D-galactopyranose (IVDG) by controlled radical (RAFT) polymerization. The anticancer drug DOX was conjugated to the deprotected copolymer (after removal of the isopropylidene group) via an acid-labile Schiff base linkage [68]. [Pg.39]

In order to obtain a faster drug release, a spacer can be introduced between the polymeric backbone and the drug, as shown in Table 10.2. Moreover, a controlled release can be obtained when the linkage between the spacer and the drug is cleavable... [Pg.290]

A polymeric pro-drug is typically composed of two distinct parts the polymer backbone or chain, and the active moieties linked to this polymer carrier by means of covalent bonds that are cleavable in the body fluids. When the drug-carrier combination circulates within the body, the carrier can transport the active principles before they exert their activity. [Pg.163]

Wei, H., Zhuo, R.-X., Zhang, X.-Z. (2013]. Design and development of polymeric micelles with cleavable links for intracellular drug delivery. [Pg.804]

See other pages where Polymeric drug cleavability is mentioned: [Pg.67]    [Pg.129]    [Pg.59]    [Pg.361]    [Pg.1172]    [Pg.98]    [Pg.6]    [Pg.7]    [Pg.359]    [Pg.217]    [Pg.287]    [Pg.89]    [Pg.204]    [Pg.11]    [Pg.215]    [Pg.249]    [Pg.61]    [Pg.330]    [Pg.89]    [Pg.204]    [Pg.441]    [Pg.179]    [Pg.183]    [Pg.85]   
See also in sourсe #XX -- [ Pg.67 ]



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Cleavability

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