Polymeric CSPs Derived from Tartaric Acid

3 Polymeric CSPs Derived from Tartaric Acid 

Another type of polymeric CSPs (Fig. 6.7) was introduced about 10 years ago by AUenmark et al. and has been commercialized under the trade name of Kromasil CHI-DMB and CHI-TTB [52-54]. 

These phases have been prepared by polymerization of N, N -diaUyl derivatives of tartardiantide and grafted onto silica gel. As these phases are crosslinked and bonded to sihca gel, they are insoluble in organic solvents and there is no limitation regarding the choice of mobile phase. Normal mode, reversed-phase and supercritical fluid conditions have been applied. They show good mechanical stability, but the relatively high content of achiral sihca gel in these CSPs reduces their loading capacity. A few preparative separations have been reported on these two CSPs (Kromasil) [52-54], but so far they have not been widely used for preparative apphcations. 

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