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Polyketide synthase heterologous expression

Roberts, G.A., Staunton, J. and Leadlay, P.F. (1993) Heterologous expression in Escherichia coli of an intact multienzyme component of the erythromycin-producing polyketide synthase. European Journal of Biochemistry, 214, 305. [Pg.259]

Jung WS, Lee SK, Hong JSJ, Park SR, Jeong SJ, Han AR, Sohng JK, Kim BG Choi CY, Sherman DH, Yoon YJ. (2006) Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae. Appl Microbiol Biotechnol 72 763-769. [Pg.628]

RJX Zawada, C Khosla. Heterologous expression, purification, reconstitution and kinetic analysis of an extended type II polyketide synthase. Chem Biol 6 607-615, 1999. [Pg.423]

These analogs were obtained through several different approaches, including heterologous expression of the modified epothilone polyketide synthases in Myccococus xanthus total chemical synthesis (spearheaded by the Danishefsky group),or biotransformation of Epo For example, the in vitro antipro-... [Pg.12]

Modular PKSs are large multifunctional enzymes. Active sites (domains) within these enzymes ketosynthases (KS), acyltransferases (AT), dehydratases (DH), enoyl reductases (ER), ketoreductases (KR), acyl carrier proteins (AGP) and thioesterases (TE) are organized into modules such that each module catalyzes the stereospecific addition of a new monomer onto a growing polyketide chain and also sets the reduction level of the carbon atoms of the resulting intermediate [70]. In 1994, the heterologous expression of the complete erythromycin polyketide synthase was accomplished. The recombinant... [Pg.19]

Shah S, Xue Q, Tang L, Carney JR, Betlach M, McDaniel R (2000) Cloning, characterization and heterologous expression of a polyketide synthase and P-450 oxidase involved in the biosynthesis of the antibiotic oleandomycin. J Antibiotic 53 502-508... [Pg.52]

R.J. Cox et al., Post-translational modification of heterologously expressed Streptomyces type 11 polyketide synthase acyl carrier proteins. FEES Lett. 405, 267-272 (1997)... [Pg.47]

See other pages where Polyketide synthase heterologous expression is mentioned: [Pg.404]    [Pg.406]    [Pg.232]    [Pg.111]    [Pg.145]    [Pg.200]    [Pg.242]    [Pg.459]    [Pg.460]    [Pg.1825]    [Pg.19]    [Pg.42]    [Pg.1025]    [Pg.314]    [Pg.496]    [Pg.480]    [Pg.17]    [Pg.673]    [Pg.194]    [Pg.66]   


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Expression synthases

Heterologous expression

Polyketide

Polyketide synthase

Polyketide synthases

Polyketides

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