Acyl-carrier protein synthase

HUANG W, JIA, J EDWARDS, P., DEHESH, K., SCHNEIDER, G., LINDQVIST, Y., Crystal structure of P-ketoacyl-acyl carrier protein synthase II from E. coli reveals the molecular architecture of condensing enzymes, EMBO J., 1998,17, 1183-1191. 

DAVIES, C., HEATH, R.J., WHITE, S.W., ROCK, C.O., The 1.8 A crystal structure and active-site architecture of P-ketoacyl-acyl carrier protein synthase HI (FabH) from Escherichia coli, Structure, 2000, 8, 185-195. 

This enzyme [EC 2.3.1.41], also known as 3-oxoacyl-[acyl-carrier protein] synthase, catalyzes the reaction of an acyl-[acyl-carrier protein] with malonyl-[acyl-carrier protein] to produce a 3-oxoacyl-[acyl-carrier protein], carbon dioxide, and the [acyl-carrier protein]. See also Fatty Acid Synthetase... 

MALONYL-CoA ACP-TRANSACYASE Acyl carrier protein synthase,... 

G D Agnolo, IS Rosenfeld, J Awaya, S Omura, PR Vagelos. Inhibition of fatty acid synthesis by the antibiotic cerulenin specific inactivation of P-ketoacyl-acyl carrier protein synthase. Biochem Biophys Acta 236 155-166, 1973. 

J-A Chuck, M McPherson, H Huang, JR Jacobsen, C Khosla, DE Cane. Molecular recognition of diketide substrates by a P-keto-acyl carrier protein synthase domain within a bimodular polyketide synthase. Chem Biol 4 757-766, 1997. 

R, Olsen, J.G., McGuire, K.A., and Henriksen, A., Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases, FEBS J. 273, 695-710, 2(X)6 Ryn, Y, Kim, KJ., Rosennser, C.A., and Scott, A., Decarboxylative Qaisen condensation catalyzed by in vitro selected ribozymes, Chem. Commun. 7, 1439-1441, 2006. 

Meier JL, Mercer AC, Rivera H, Burkart MD. Synthesis and 36. evaluation of bioorthogonal pantetheine analogues for in vivo protein modification. J. Am. Chem. Soc. 2006 128 12174-12184. Lambalot RH, Walsh CT. Cloning, overproduction, and characterization of the Escherichia-coli Holo-Acyl carrier protein synthase. 37. 

Davies, C., Heath, R. I., White. 3. W.. and Rock, C. O. 2000. The l. A crystal structure and active site architecture of p-kctoacyl-acyl carrier protein synthase 111 (EabH) from Eschen t/iiu co i. StrudurcfoM... 

Lambalot, R. H. Walsh, C.T. Cloning, overproduction, and characterization of the Escherichia coli holo-acyl carrier protein synthase. 

Lee, J.Y., Jeong, KW., Lee, J.U., Kang, D.I., and Kim, Y. (2009) Novel E. coli beta-ketoacyl-acyl carrier protein synthase III inhibitors as targeted antibiotics. Bioorganic ei Medicinal Chemistry, 17, 1506-1513. 

Nomura, C., Tanaka, T., Gan, Z., Kuwabara, K., Abe, H., Takase, K., Taguchi, K., Doi, Y. Effective enhancement of short-chain-length-medium-chain-length polyhydroxyalkanoate copolymer production by coexpression of genetically engineered 3-ketoacyl-acyl-carrier-protein synthase III (fabH) and polyhydroxyalkanoate synthesis genes. Biomacromolecules 5(4), 1457-1464 (2004)... 

Tai, H Jaworski, JG. 3-Ketoacyl-acyl carrier protein synthase III from spinach (Spinacia oleraced) is not similar to other condensing enzymes of fatty acid synthase. 

Synthetic apo-ACP protein, a polypeptide representing amino acids 2-74 of the E. coli protein, functions as substrate for the holo-acyl-carrier protein synthase (EC 2.7.S.7) the product has the same biological activity as natural holo-ACP. 

Sohby C. Regulation of fatty acid synthetase activity. J Biol Chem 1979 254 8561-8566. ElhusseinSA, MiemykJA, OhlroggeJB. Plant holo-(acyl carrier protein) synthase. Biixzhem J 1988 252 39-45. 

Meurer G, Hutchirtson CR. Functional analysis of putative p-ketoacyl acyl carrier protein synthase and acyltrartsferase active Sice motik in a type 11 polyketide synthase of Strep mycesglaucescens. J Bacteriol 1995 177 477-481. 

Siggaard-Andersen, M., Wissenbach. M., Chuck, J.-A., Svendsen, I., Olsen, J.G., and Wettstein-Knowles, P. von (1994) The Ta J-encoded p-ketoacyl-[acyl carrier protein] synthase IV from Escherichia coli is sensitive to cerulenin and specific for short-chain substrates. Proc. Natl. Acad. Sci. USA 91 11027-11031. 

Clough, R.C., Matthis, A.L., Barnum, S.R. and Jaworski, J.G. (1992) Purification and characterization of 3-ketoacyl-acyl carrier protein synthase III from spinach. A condensing enzyme utilizing acetyl-coenzyme A to initiate fatty acid synthesis. J. Biol. Chem. 267, 20992-20998. 

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