Polyhalogenated aromatic hydrocarbon

TEF Values for Polyhalogenated Aromatic Hydrocarbons Used in a Study of Residues in Fish... 

Murk, A.J., T.J. Boudewijn, P.L. Meininger, A.T.C. Bosveld, G. Rossaert, T. Ysebaert, P. Meire, and S. Dirksen. 1996. Effects of polyhalogenated aromatic hydrocarbons and related contaminants on common tern reproduction integration of biological, biochemical, and chemical data. Arch. Environ. Contam. Toxicol. 31 128-140. 

Immune Modulation byTCDD and Related Polyhalogenated Aromatic Hydrocarbons... 

Murk, A.J., Bosveld, A.T.C., Berg, M. van den and Brouwer, A. (1994a). Effects of polyhalogenated aromatic hydrocarbons (PHAHs) on biochemical parameters in chicks of the common tern (Sterna Hirundo). Aquat. Toxicol. 30(2), 91-115. 

Murk, A. J., Leonards, P.E.G., VanHattum, B., Luit, R., Van der Weiden, M., Smit, M.D. (1998). Application of biomarkers for exposure and effects of polyhalogenated aromatic hydrocarbons in naturally exposed European otters (Lutra lutra). Environ Toxicol Phar-macol 6 91—102. 

Brouwer A. 1998. Structure-dependent multiple interactions of polyhalogenated aromatic hydrocarbons with the thyroid hormone system. Organohalogen Compounds 37 225-232. 

Sanderson JT, Aarts JMMJG, Brouwer A, et al. 1996. Comparison of Ah receptor-mediated luciferase and ethoxyresorufm-O-deethylase induction in H4IIE cells Implications for their use as bioanalytical tools for the detection of polyhalogenated aromatic hydrocarbons. Toxicol Appl Pharmacol 137 316-325. 

Dioxins (PCDDs) and furans (PCDFs) are polyhalogenated aromatic hydrocarbons of high toxicity. There are a total of 210 different congeners 75 dioxin congeners and 135 furan congeners, of which 17 are potentially toxic. Dioxins and furans are now found prevalent in air, water, and soil in almost all natural environments. PCDD/Fs are strongly bound to organic matter, where half-life in soil has been estimated at 10-20 years (Ryan et al., 1987). PCDD/Fs enter the environment primarily as unintentional byproducts of combustion and chemical processes. 

Jackson, J.A., Diliberto, J.J., Bimbaum, L.S. (1993) Estimation of octanol-water partition coefficients and correlation with dermal absorption for several polyhalogenated aromatic hydrocarbons. Fundam. Appl. Toxicol. 21, 334-344. 

Polyhalogenated aromatic hydrocarbons (e.g. hex-achlorobenzene (HCB, CeCle) and polychorobiphenyls (PCBs)) are rapidly degraded by superoxide ion in DMF to bicarbonate and halide ions. Because halogen-bearing intermediates are not detected, the initial nucleophilic attack is the rate-determining step. The rates of reaction exhibit a direct correlation with the electrophilicity of the substrate (reduction potential) (e.g. CeCle, E° = -1.48 V vs. SCE ki/[S] = 1 X lO M- s and 1,2,4-C6H3C13, E° = -2.16 V ki/[S] = 2x 10-2 M- s ). 

The toxicities of polyhalogenated aromatic hydrocarbons are elaborated upon in the chapters of Part 3 of this book. 

Polyhalogenated aromatic hydrocarbons TCDD (2,3,7,8-tetrachlorodibenzo p dioxin), PBB (polybromated biphenyls), PCDF (polychlorinated dibenzofuran), PCBs (polychlorinated biphenyls), hexachloro benzene, 2,4- dichlorophenol Appears to correlate with carcinogenic effect. Case studies for PCB and organochlorine pesticides resulted infections associated with immunosuppression... 

Voorman, R. and S.D. Aust (1987). Specific binding of polyhalogenated aromatic hydrocarbon inducers of cytochrome P-450j to the cytochrome and inhibition of its estradiol 2-hydroxylase activity. Toxicol. Appl. Pharmacol. 90, 69-78. 

The reduction reaction of an aromatic halide is also useful for destruction of highly toxic polyhalogenated aromatic hydrocarbons (PCBs) (Safe and Hutzinger, 1987). 

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