Polyfunctional Silicon Organometallics for Organic Synthesis

In this chapter, we describe preparation of polyfunctional organosilicon reagents and demonstrate their high versatility by selecting some recent examples of allylic silanes, alkenylsilanes, alkylsilanes, and miscellaneous types of silanes, in which C-Si bonds are utilized as C-Metal ones to be converted into C-C bonds. 

Copyright 2005 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim ISBN 3-527-31131-9 

Stereocontrol [5], Similar chiral crotyl-type silane 5 undergoes double stereodifFer-entiating crotylation reaction of chiral aldehyde (S)-6 in the presence of TiCh as the Lewis acid promoter [6]. The utility of the reaction is demonstrated by total synthesis of oleandolide [7]. 

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