Polyfe-caprolactone PCL

As widely usable biodegradable materials, PLA is found to exhibit too hard and too brittle characters. The weakness might be improved when a polymer with lower glass transition temperature is used together [18]. Polyfe-caprolactone) (PCL) and poly(glycolic acid) (PGA), also known as polyglycolide, are two other... 

Microscopic evidence for pH-sensitive triggered intracellular release of the payload from Pluronic-modified PBAE nanoparticles. F-108-modified polyfs-caprolactone) (PCL) nanoparticles served as a non-pH-responsive control. Fluorescently-labeled modified PBAE or PCL nanoparticles were added to MDA-MB-231 human breast adenocarcinoma cells at 37°C.The first column shows the images from differential interference contrast microscopy. 

The most common bio-aliphatic polyesters are poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), polyfe-caprolactone) (PCL), and poly(3-hydroxybutyrate) (PHB). While PLA, PLGA, and PHB are bio-based, PCL is obtained from the chemical conversion of crude oil. But all of them are biodegradable and biocompatible. Thus, they attract increasing attention in biomedical applications. However, the biopolyesters present poor thermal stability with respect of traditional oil-based polyesters. 

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