Polyester degradation by hydrolysis

The present paper reports on a study which was conducted to investigate the effect of NaOH on the in vitro release profiles of microspheres prepared with polylactides (2) Since these polyesters degrade by hydrolysis (4), it is possible that the molecular weight of the polymers can be decreased by the alkaline pH of the sodium oleate emulsifier solution (pH 10) during fabrication. This in turn could affect the release kinetics of the microspheres. 

After exposure to and equilibration in an aqueous environment, polyesters degrade by hydrolysis that occurs homogeneously throughout the bulk of the... 

Poly(e-caprolactone) Aliphatic polyester Degraded by hydrolysis or bulk erosion Slow degrading Degradation products incorporated in the tricarboxylic acid cycle Low chemical versatility Some problems related with withstanding mechanical loads... 

As the major requirement of tissue engineering scaffolds, those polyesters and their monomers should be biocompatible with human bodies. Polyesters degrade by hydrolysis of the ester bond. PGA is hydrophilic in nature and it degrades rapidly in vitro aqueous solution or in vivo fast. PLA is more hydrophobic than PGA because of the extra methyl group in the repeating units. 

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See also in sourсe #XX -- [ ]

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