Polyene antifungals

Polymyxins Polyene antifungals Inhibition of synthesis or damage to cytoplasmic membrane... 

Oroshnik, W., Mebane, A. D. The Polyene Antifungal Antibiotics in Fortschritte der Chemie Organischer Naturstoffe (Zechmeister, L, ed,), Springer Verlag, Wien 1963, vol. 21, p. 17... 

Griseofulvin and terbinafine are indicated in the management of fungal nail infections. Nystatin (polyene antifungal) is indicated in the management of Candida infections and is not indicated for fungal nail infections. 

Nystatin is a polyene antifungal, v/hich may be used orally for the treatment of intestinal candidiasis. 

Kakeya H, Miyazaki Y, Senda H, Kobayashi T, Seki M, Izumikawa K, Yanagihara K, Yamamoto Y, Tashiro T, Kohno S. (2008) Efficacy of SPK-843, a novel polyene antifungal, in comparison with amphotericin B, liposomal amphotericin B, and micafungin against murine pulmonary aspeTgillo i. Antimicrob Agents Chemother 52 1868-1870. 

Amphotericin B (Fungizone), a polyene antifungal drug produced by the actinomycete Streptomyces nodosus, consists of a large ring structure with both hydrophilic... 

Nystatin (Mycostatin) is a polyene antifungal drug with a ring structure similar to that of amphotericin B and a mechanism of action identical to that of amphotericin B. Too toxic for systemic use, nystatin is limited to the topical treatment of superficial infections caused by C albicans. Infections commonly treated by this drug include oral candidiasis (thrush), mild esophageal candidiasis, and vaginitis. 

Mechanism of Action A polyene antifungal agent that increases cell membrane permeability in susceptible fungi. Therapeutic Effect Fungicidal. 

W. Mechlinski and C. P. Schaffner, Separation of polyene antifungal antibiotics by high-speed liquid chromatography, J. Chromatogr., 99 619 (1974). 

The best-known polyene antifungal drug is Amphotericin B, whose structure is shown below. 

One compound that has been associated with distal tubular injury is amphotericin B, a polyene antifungal agent used in the treatment of systemic mycoses caused by opportunistic fungi. Clinical utility of amphotericin B is limited by its nephrotoxicity, characterized functionally by polyuria resistant to antidiuretic hormone administration, hyposthenuria, hypokalemia, and mild renal tubular acidosis. 

Kinsky SC, Avruch J, Permutt M, Rogers HB.The lytic effect of polyene antifungal antibiotics on mammalian erythrocytes. Biochem Biophys ResCommun 1962 9 503-7. 

Natamycin belongs to the large group of polyene antifungal antibiotics. Characteristic for this group is a macrocyclic lactone-ring with a number of conjugated carbon-carbon double bonds. 

Disruption of cell membrane function Azole and polyene antifungal agents... 

B. (2000). Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455 Analysis of the gene cluster and deduction of the biosynthetic pathway. Chem. Biol. 7, 395 03. 

Group 6 is the family of polyenic, antifungal antibiotics, many members of which carry an amino sugar moiety it includes nystatin, amphotericin, and rimocidin. 

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