Polyelectrolyte multilayers biocompatibility

Gheith, M. K., Sinani, V. A., Wicksted, J. P., et al. (2005) Single-walled carbon nanotube polyelectrolyte multilayers and freestanding films as a biocompatible platformfor neuropros-thetic implants. Adv. Mat. 17, 2663-70. 

W., Chen, L Wang, H., Mo, X., and Zhang, Y. (2013) Polyelectrolyte multilayer functionalized mesoporous silica nanoparticles for pH-responsive drug delivery layer thickness-dependent release profiles and biocompatibility. / Mater. Chem. B, 1 (43), 5886-5898. 

This chapter deals with the layer-by-layer (LbL) assembly of polyelectrolyte multilayers of polypeptides (poly L-ly sine/poly L-glutamic acid) and polysaccharides (chitosan/dextran suliate) onto soft and porous thermo-responsive poly (N-isopropylacrylamide-co-methacrylic acid) (P(NiPAM-co-MAA)) nanogels. The formation of the LbL structures and characterization of hydro-dynamic radius, electrophoretic mobility, bilayer thickness and stability over time of the systems will be comparatively discussed. Further, the assembly of biopolymers onto similar microgels will be analyzed. The results presented demonstrate that the structure and properties of biocompatible multilayer films can be finely tuned by confinement onto soft and porous gels, which provides new perspectives for biomedical plications, particularly storage and controlled release of biomolecules. 

To begin with, multilayers can be used to modify surfaces, and in particular their biocompatibility (e.g., for implants) [174,186,206,332] or their wettability (e.g., for antifogging mirrors or eyeglasses) [153]. Obviously, only a limited number of layers is needed for these applications here, the fact that polyelectrolyte adsorbs readily on various substrates is a clear advantage. 

Karamitros CS, Yashchenok AM, Mohwald H, Skirtach AG, Konrad M (2013) Preserving catalytic activity and enhancing biochemical stability of the therapeutic enzyme asparaginase by biocompatible multilayered polyelectrolyte microcapsules. Biomactomolecules 14 4398 406... 

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